The American Academy of Sleep Medicine Invites Public Comment

March 14, 2024 The American Academy of Sleep Medicine Invites Public Comment By Adrianna Colucci, RLS Foundation Administrative ...

March 14, 2024

The American Academy of Sleep Medicine Invites Public Comment

By Adrianna Colucci, RLS Foundation Administrative Assistant

The American Academy of Sleep Medicine (AASM) is inviting public comment through April 9th on the newly drafted clinical practice guidelines and systematic review of the Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder. These new guidelines will synthesize the RLS treatment therapies that are now recommended for adult and pediatric populations, updating the previous 2012 AASM RLS guidelines. In these guidelines, treatments were scored as either “strong” or “conditional” (strongly for, strongly against, etc.) The systematic review provides further insight and research data to support the accompanying guidelines. A video overview highlighting the signifcant changes is also available.

Interested members of the public are encouraged to provide feedback on the drafted guidelines to the AASM. From healthcare professionals to advocacy groups to RLS patients and caregivers – all can provide important comments. Varying evidence has value, including both clinical experience and published articles. Public participation ensures that the guidelines meet the needs of the medical and RLS patient communities. Responses should include questions and perspectives that are appropriate, respectful and relevant to the subject.

Comments can be made Tuesday, March 12th through Tuesday, April 9th. To submit comments, complete the disclosure form and email it alongside your comments and questions to

Revisions to the draft guideline and systematic review are at the discretion of the task force, but all submitted comments will be considered and responses internally documented before the guidelines are submitted to the AASM Board of Directors for approval for publication in the Journal of Clinical Sleep Medicine.

Disclaimer: The recommendations in the clinical practice guideline manuscript are in draft form and are still subject to substantive changes by the time they are published in final form. They should not be copied, disseminated, or implemented until final publication.

Helpful Abbreviations

  • AASM: American Academy of Sleep Medicine
  • CPG: Clinical practice guidelines
  • CST: Clinical significance threshold
  • IRLSSG: International Restless Legs Syndrome Study Group
  • PICO: Patient, Intervention, Comparison, and Outcomes questions
  • PLMD: Periodic limb movement disorder
  • QOL: Quality of life
  • GRADE: Grading of Recommendations Assessment, Development and Evaluation methodology
  • RCT: Randomized controlled trial
  • SR: Systematic review
  • TF: Task force
  • WASO: Wake after sleep onset

Translation from Generic Brand Name to Common Brand Names

  • Bupropion: Wellbutrin
  • Cabergoline: Dostinex
  • Carbamazepine: Tegretol
  • Clonazepam: Klonopin
  • Dipyridamole: Persantin
  • Ferric carboxymaltose: Injectafer
  • Ferrous sulfate: various iron brand names
  • Gabapentin enacarbil: Horizant
  • Gabapentin: Neurontin; Gralise
  • Levodopa: Sinemet
  • Low-molecular-weight iron dextran: INFeD
  • Oxycodone: Oxycontin
  • Pramipexole: Mirapex
  • Pregabalin: Lyrica
  • Transdermal rotigotine: Neupro patch
  • Valproic acid: Depakote

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